For an oocyte to get ready for fertilization and progress into an embryo, the proper list of genes ought to be turned on. Namekawa suspected this pre-programming on the oocyte genome occurs in various levels — the very first 1 setting up round the time a feminine is born. He thought that chromatin remodeling proteins did much of this function, by shifting spools all over.
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Munakata and Namekawa will Examine mice with normal and mutated versions of your chromatin remodeler. Since the mice grow and mature, they may observe if the existence or absence of the protein triggers distinctions in the arrangement of DNA spools in the animals’ oocytes. And they'll observe whether this, subsequently, alters the pattern of gene expression after a while.
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